Gene Therapy
New gene therapy study findings have been reported by researchers at Case Western Reserve University, Medical Department
Published in Women's Health Weekly, October 23rd, 2008
According to a study from the United States, "Estrogen receptor alpha (ER alpha) plays a key role in mammary gland development and is implicated in breast cancer through the transcriptional regulation of genes linked to proliferation and apoptosis. We previously reported that hexamethylene bisacetamide inducible protein 1 (HEXIM1) inhibits the activity of ligand-bound ER alpha. and bridges it functional interaction between ER alpha and positive transcription elongation factor b (P-TEFb)."
"To examine the consequences of a functional HEXIM1-ER alpha-P-TEFb interaction in vivo, we generated MMTV/HEXIM1 mice that exhibit mammary epithelial-specific and...
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