Women's Health Weekly
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Life Sciences
Reports summarize life sciences research from University of Quebec
October 23rd, 2008
"We have recently reported the synthesis of a platinum(II) complex, made of estradiol, the female sex hormone, and a cisplatin analog, an anticancer drug, linked together by an eleven carbon atoms chain. The novel estradiol-Pt(II) hybrid molecule was synthesized in nine chemical steps with 10% overall yield," scientists writing in the journal Steroids report. "This new compound has been tested in Vitro on estrogen-dependent (MCF-7) and -independent (MDA-MD-231) (ER+ and ER-) cell lines. Interestingly, the biological activity was quite significant, more potent than that of cisplatin, the compound currently used in chemotherapy The estrogen receptor binding...
Source: Women's Health Weekly (2008-10-23)
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