Women's Health Weekly
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Breast Cancer
Recent studies by R.I. Yarden and co-authors add new data to breast cancer findings
October 30th, 2008
"A functional single nucleotide polymorphism in the promoter of the MDM2 gene, SNP309 (T > G), was recently found to accelerate tumorigenesis in early onset cancer cases. The SNP309 G-allele, introduces an SP1 site in the MDM2 promoter, resulting in enhanced MDM2 expression and activity," researchers in Tel Hashomer, Israel report. "Thus, the G-allele of MDM2 SNP309 may represent a cancer predisposing allele. In this report, we assessed the role of SNP309 as a modifier of mutant BRCA1/BRCA2 alleles in inherited breast and ovarian cancer cases among Ashkenazi-Jewish (AJ) women. We genotyped several subsets of AJ women: 138 healthy women, 140 affected BRCA1/2 mutation...
Source: Women's Health Weekly (2008-10-30)
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