Women's Health Weekly
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Breast Cancer
Recent studies from University Medical Center add new data to breast cancer
October 30th, 2008
"Hypoxia is a hallmark of cancer. Hypoxia inducible factor-1 alpha (HIF-1 alpha) is the key regulator of the hypoxia response," scientists in Netherlands report. "HIF-1 alpha is overexpressed during sporadic breast carcinogenesis and correlated with poor prognosis. Little is known on the role of HIF-1 alpha in hereditary breast carcinogenesis. A recent study suggests a role for BRCA1 in HIF-1 alpha regulation. We therefore examined the expression of HIF-1 alpha in BRCA1 related breast cancers. By immunohistochemistry we studied expression of HIF-1 alpha and some of its downstream targets in 30 hereditary invasive breast cancers in comparison with 200 sporadic controls....
Source: Women's Health Weekly (2008-10-30)
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