Women's Health Weekly
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Breast Cancer
Reports from Tufts University, Medical Department advance knowledge in breast cancer
October 30th, 2008
According to recent research from the United States, "The 4T1 mouse mammary tumor cell line is one of only a few breast cancer models with the capacity to metastasize efficiently to sites affected in human breast cancer. Here we describe two 4T1 cell lines modified to facilitate analysis of tumor growth and metastasis and evaluation of gene function in vivo." "New information regarding the involvement of innate and acquired immunity in metastasis and other characteristics of the model relevant to its use in the study of late stage breast cancer are reported. The lines were engineered for stable expression of firefly luciferase to allow tracking and quantitation of the...
Source: Women's Health Weekly (2008-10-30)
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