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Women's Health Weekly

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Breast Cancer



Reports on breast cancer findings from University of Palermo provide new insights



October 30th, 2008

"It was previously reported that the midregion PTHrP domain (38-94)-amide restrains growth and invasion ''in vitro'', causes striking toxicity and accelerates death of some breast cancer cell lines, the most responsive being MDA-MB231 whose tumorigenesis was also attenuated ''in vivo''. In addition, we have demonstrated that midregion PTHrP is imported in the nucleoplasm of cultured MDA-MB231 cells, and that ''in vitro'' it can bind chromatin of metaphase spread preparations and also an isolated 20-mer oligonucleotide, thereby appearing endowed with a putative transcription factor-like DNA-binding ability," researchers in Palermo, Italy report.

"Here, we examined...


Source: Women's Health Weekly (2008-10-30)

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