Women's Health Weekly
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Breast Cancer
Reports on breast cancer findings from University of Palermo provide new insights
October 30th, 2008
"It was previously reported that the midregion PTHrP domain (38-94)-amide restrains growth and invasion ''in vitro'', causes striking toxicity and accelerates death of some breast cancer cell lines, the most responsive being MDA-MB231 whose tumorigenesis was also attenuated ''in vivo''. In addition, we have demonstrated that midregion PTHrP is imported in the nucleoplasm of cultured MDA-MB231 cells, and that ''in vitro'' it can bind chromatin of metaphase spread preparations and also an isolated 20-mer oligonucleotide, thereby appearing endowed with a putative transcription factor-like DNA-binding ability," researchers in Palermo, Italy report. "Here, we examined...
Source: Women's Health Weekly (2008-10-30)
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