Breast Cancer
Reports on breast cancer findings from University of Palermo provide new insights
Published in Women's Health Weekly, October 30th, 2008
"It was previously reported that the midregion PTHrP domain (38-94)-amide restrains growth and invasion ''in vitro'', causes striking toxicity and accelerates death of some breast cancer cell lines, the most responsive being MDA-MB231 whose tumorigenesis was also attenuated ''in vivo''. In addition, we have demonstrated that midregion PTHrP is imported in the nucleoplasm of cultured MDA-MB231 cells, and that ''in vitro'' it can bind chromatin of metaphase spread preparations and also an isolated 20-mer oligonucleotide, thereby appearing endowed with a putative transcription factor-like DNA-binding ability," researchers in Palermo, Italy report.
"Here, we examined...
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