Women's Health Weekly
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Breast Cancer
Research reports from McGill University provide new insights into breast cancer
October 30th, 2008
According to recent research from Montreal, Canada, "BRCA1 and BRCA2 account for the majority of the known familial breast cancer risk, however, the impact of other cancer susceptibility genes largely remains to be elucidated. Checkpoint Kinase 2 ( CHEK2) is an important signal transducer of cellular responses to DNA damage, whose defects have been associated with an increase in breast cancer risk." "Previous studies have identified low penetrance CHEK2 alleles such as 1100delC and 1157T, as well as variants such as S428F in the Ashkenazi Jewish population and IVS2 + IG > A in the Polish population. No founder allele has been specifically identified in the French...
Source: Women's Health Weekly (2008-10-30)
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