Women's Health Weekly
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Breast Cancer
Data on breast cancer published by researchers at Thomas Jefferson University
November 6th, 2008
According to a study from the United States, "Decreased expression of specific microRNAs ( miRNAs) occurs in human tumors, which suggests a function for miRNAs in tumor suppression. Herein, levels of the miR-17-5p/miR-20a miRNA cluster were inversely correlated to cyclin D1 abundance in human breast tumors and cell lines." "MiR-17/20 suppressed breast cancer cell proliferation and tumor colony formation by negatively regulating cyclin D1 translation via a conserved 3 ' untranslated region miRNA-binding site, thereby inhibiting serum-induced S phase entry. The cell cycle effect of miR-17/20 was abrogated by cyclin D1 siRNA and in cyclin D1-deficient breast cancer cells....
Source: Women's Health Weekly (2008-11-06)
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