Women's Health Weekly
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Breast Cancer
Research from D. Voduc and colleagues provide new insights into breast cancer
November 6th, 2008
"Gene expression studies have identified a basal phenotype of breast cancer; these are hormone receptor and HER2-negative cancers with poor prognosis. High levels of cyclin E and Skp2, and low levels of p27 have previously been individually associated with both basal-like breast cancer and a poor outcome after diagnosis," researchers in Vancouver, Canada report. "The goal of this study was to first confirm the prognostic value of these biomolecular markers using a breast cancer tissue microarray. Second, we also test the hypothesis that the combined phenotype of high cyclin E, low p27, and high Skp2 would be a strong predictor of outcome and would be closely associated...
Source: Women's Health Weekly (2008-11-06)
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