Women's Health Weekly
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Breast Cancer
Reports from Vanderbilt University, Medical Department advance knowledge in breast cancer
November 13th, 2008
"The transforming growth factor-beta (TGF-beta) signaling pathway plays dual roles in epithelial cell turnorigenesis. TGF-beta is initially growth inhibitory, but as tumorigenesis progresses, TGF-beta becomes prometastatic," researchers in the United States report. "Although the role of the types I and II TGF-beta receptors is fairly well established, the role of the ubiquitously expressed TGF-beta type III receptor (T beta RIII) in tumorigenesis is less defined. To examine the role of T beta RIII in breast cancer cells, we stably expressed short hairpin RNAs specific to T beta RIII in MDA-231 human breast cancer cells and mouse mammary carcinoma cells expressing the...
Source: Women's Health Weekly (2008-11-13)
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