Women's Health Weekly
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Breast Cancer
Data from National Cancer Institute advance knowledge in breast cancer
November 13th, 2008
"The paradigm of mammary cancer induction by the mouse mammary tumor virus (MMTV) is used to illustrate the body of evidence that supports the hypothesis that mammary epithelial stem/progenitor cells represent targets for oncogenic transformation. It is argued that this is not a special case applicable only to MMTV-induced mammary cancer, because MMTV acts as an environmental mutagen producing random interruptions in the somatic DNA of infected cells by insertion of proviral DNA copies," investigators in the United States report. "In addition to disrupting the host genome, the proviral DNA also influences gene expression through its associated enhancer sequences over...
Source: Women's Health Weekly (2008-11-13)
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