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Women's Health Weekly

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Breast Cancer



Data on breast cancer published by F. Puglisi and colleagues



November 13th, 2008

"Preclinical data have indicated a synergistic interaction between docetaxel and capecitabine by means of taxane-induced up-regulation of thymidine phosphorylase (TP). On the basis of such premises, we conducted a phase II trial to determine the activity and tolerability of weekly docetaxel plus capecitabine in patients with metastatic breast cancer (MBC)," researchers in Udine, Italy report.

"Furthermore, we explored the relationship between TP tumor expression and benefit from this regimen. Patients received docetaxel 36 mg/m(2) i.v. on days 1, 8, and 15 and capecitabine orally 625 mg/m(2) b.i.d. from days 8 to 21. Cycles were repeated every 4 weeks. In the...


Source: Women's Health Weekly (2008-11-13)

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