Women's Health Weekly
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Breast Cancer
New breast cancer research reported from University of Frankfurt
November 20th, 2008
According to a study from Frankfurt, Germany, "Beside their structural role for the cell membrane the family of sphingolipids act as effector molecules in signal transduction with links to various aspects of cancer initiation, progression and treatment response. The ''sphingolipid rheostat'' balances between apoptosis inducing ceramid and growth promoting sphingosine-1-phosphate." "We analyzed gene expression of 43 proteins from this pathway in different subtypes of breast cancer using microarray data of 1,269 tumor samples (test set n = 171; validation sets n = 1098) and observed significant differences for several genes. Sphingosine kinase 1 (SPHK1), ceramide...
Source: Women's Health Weekly (2008-11-20)
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