Women's Health Weekly
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Breast Cancer
Research data from M. Aubele and colleagues update understanding of breast cancer
November 20th, 2008
According to a study from Neuherberg, Germany, "The cytoplasmic tyrosine kinase PTK6 (BRK) shows elevated expression in approximately two-thirds of primary breast tumours, and is implicated in EGF receptor-dependent signalling and epithelial tumorigenesis. Using immunohistochemistry, we performed a retrospective study on 426 archival breast cancer samples from patients with long-term follow-up and compared the protein expression levels of PTK6, the HER receptors, Sam68 (a substrate of PTK6), and signalling proteins including MAP kinase (MAPK), phosphorylated MAPK (P-MAPK), and PTEN." "We show that PTK6 expression is of significant prognostic value in the outcome of...
Source: Women's Health Weekly (2008-11-20)
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