Women's Health Weekly
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Breast Cancer
Data on breast cancer detailed by researchers at Cardiff University, Medical Department
November 27th, 2008
"Claudin-16 (Paracellin-1) is a transmembrane tight junction (TJ) protein originally described as having a critical role in the re-absorption of magnesium and calcium in the kidney. This study examined expression of Claudin-16 in human breast cells and tissues to identify a possible link between expression and aggressiveness in cells and between Claudin-16 levels and patient prognosis," scientists in Wales report. "Insertion of the Claudin-16 gene into MDA-MB-231 human breast cancer cells resulted in cells that were significantly less motile and invasive in behavior, with increased adhesion to matrix. These cells also exhibited significantly increased TJ functionality...
Source: Women's Health Weekly (2008-11-27)
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