Women's Health Weekly
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Breast Cancer
Investigators at National Institutes of Health zero in on breast cancer
November 27th, 2008
According to recent research published in the journal Oncogene, "Metastasis is the primary cause of death in patients with breast cancer. Overexpression of c-myc in humans correlates with metastases, but transgenic mice only show low rates of micrometastases." "We have generated transgenic mice that overexpress both c-myc and vascular endothelial growth factor (VEGF) (Myc/VEGF) in the mammary gland, which develop high rates of pulmonary macrometastases. Gene expression pro. ling revealed a set of deregulated genes in Myc/VEGF tumors compared to Myc tumors associated with the increased metastatic phenotype. Cross-comparisons between this set of genes with a human...
Source: Women's Health Weekly (2008-11-27)
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