Women's Health Weekly
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Breast Cancer
New breast cancer findings from A.C. Marchiori and co-authors described
November 27th, 2008
"Most breast cancer risk factors are associated with prolonged exposure of the mammary gland to high levels of estrogens. The actions of estrogens are predominantly mediated by two receptors, ER alpha and ER beta, which act as transcription factors binding with high affinity to estrogen response elements in the promoter region of target genes," investigators in Sao Paulo, Brazil report. "However, most target genes do not contain the consensus estrogen response elements, but rather degenerated palindromic sequences showing one or more mutations and other ER-binding sites such as AP-1 and SP-1. Using the differential display reverse transcription-polymerase chain reaction...
Source: Women's Health Weekly (2008-11-27)
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