Women's Health Weekly
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Breast Cancer
New findings from Massachusetts General Hospital describe advances in breast cancer
November 27th, 2008
According to recent research published in the British Journal of Cancer, "Germline mutations in both BRCA2 and CHEK2 are associated with an increased risk for male breast cancer. To search for potential interactions between the products of these breast cancer susceptibility genes, we undertook systematic mapping of BRCA2 for potential phosphorylation sites by CHEK2." "In vitro kinase assays and mass spectrometric analysis identified a 50 amino-acid fragment within the N-terminus of BRCA2 potentially targeted by CHEK2, containing two major phosphopeptides. Inducible overexpression of this peptide, but not a derivative with mutated phosphorylation sites, leads to...
Source: Women's Health Weekly (2008-11-27)
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