Women's Health Weekly
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Breast Cancer
Reports from D. Bhaumik and colleagues advance knowledge in breast cancer
November 27th, 2008
"Cancer cells often acquire a constitutively active nuclear factor-kappa B (NF-kappa B) program to promote survival, proliferation and metastatic potential by mechanisms that remain largely unknown. Extending observations from an immunologic setting, we demonstrate that microRNA-146a and microRNA-146b (miR-146a/b) when expressed in the highly metastatic human breast cancer cell line MDA-MB-231 function to negatively regulate NF-kappa B activity," scientists in the United States report. "Lentiviral-mediated expression of miR-146a/b significantly downregulated interleukin (IL)-1 receptor-associated kinase and TNF receptor-associated factor 6, two key adaptor/scaffold...
Source: Women's Health Weekly (2008-11-27)
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