Women's Health Weekly
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Breast Cancer
Reports on breast cancer findings from Lund University provide new insights
November 27th, 2008
"It is well known that the positively charged polyamines have a DNA-stabilizing function and that polyamine depletion alters chromatin function. We have previously shown that polyamine depletion causes an S phase prolongation, and others have shown that there is an accumulation of Okazaki-like fragments in polyamine-depleted cells," scientists in Lund, Sweden report. "In the present study, we have used the comet assay to investigate polyamine depletion-induced DNA strand breaks. Three breast cancer cell lines and one normal-like breast cell line were treated with the polyamine analogue N-1,N-11-diethylnorspermine or with the polyamine biosynthesis inhibitor...
Source: Women's Health Weekly (2008-11-27)
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