Women's Health Weekly
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Breast Cancer
Researchers from Mayo Clinic, Medical Department report on findings in breast cancer
November 27th, 2008
"Tandem breast cancer C-terminal (BRCT) domains, present in many DNA repair and cell cycle checkpoint signaling proteins, are pbosphoprotein binding modules. The best-characterized tandem BRCT domains to date are frorn the protein BRCA1 (BRCA1-BRCT), an E3 ubiquitin ligase that has been linked to breast and ovarian cancer," researchers in the United States report. "While X-ray crystallography and NMR spectroscopy studies have uncovered the structural determinants of specificity of BRCA1-BRCT for phosphorylated peptides, a detailed kinetic and thermodynamic characterization of the interaction is also required to understand how structure and dynamics are connected and...
Source: Women's Health Weekly (2008-11-27)
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