Women's Health Weekly
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Breast Cancer
Scientists at Wageningen University target breast cancer
November 27th, 2008
According to recent research published in the journal Toxicological Sciences, "Breast cancer cells show overexpression of estrogen receptor (ER) alpha relative to ER beta compared to normal breast tissues. This observation has lead to the hypothesis that ER beta may modulate the proliferative effect of ER alpha." "This study investigated how variable cellular expression ratios of the ER alpha and ER beta modulate the effects on cell proliferation induced by ER alpha or ER beta agonists, respectively. Using human osteosarcoma (U2OS) ER alpha or ER beta reporter cells, propyl-pyrazole-triol (PPT) was shown to be a selective ER alpha and diarylpropionitrile (DPN) a...
Source: Women's Health Weekly (2008-11-27)
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