Women's Health Weekly
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Breast Cancer
Research reports from University of Montreal provide new insights into osteoarthritis
December 4th, 2008
"Overproduction of nitric oxide (NO) and prostaglandin E-2 (PGE(2)) plays an important role in the pathogenesis of osteoarthritis (OA). In the present study. we determined the effect of trichostatin A (TSA) and butyric acid (BA), two histone deacetylase (HDAC) inhibitors, on NO and PGE2 synthesis, inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 expression, and nuclear factor (NF)-kappa B DNA-binding activity, in interleukin-1 beta (IL-1)-stimulated human OA chondrocytes, and on IL-1-induced proteoglycan degradation in cartilage explants," scientists writing in the journal Osteoarthritis and Cartilage report. "Chondrocytes were stimulated with IL-1 in the...
Source: Women's Health Weekly (2008-12-04)
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