Women's Health Weekly
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Breast Cancer
Study findings from University of Louvain provide new insights into breast cancer
December 4th, 2008
" Polysomy 17 is frequently found in breast cancer and may complicate the interpretation of HER-2 testing results. We investigated the impact of polysomy 17 on HER-2 testing and studied its clinicopathologic significance in relation to HER2 gene amplification," researchers in Louvain, Belgium report. "Patients and Methods In 226 patients with primary invasive breast carcinoma, HER2 gene and chromosome 17 copy numbers were determined by dual-color fluorescent in situ hybridization (FISH). The interpretation of FISH results was based on either absolute HER2 gene copy number or the ratio HER2/chromosome 17. Results were correlated with HER-2 protein expression on...
Source: Women's Health Weekly (2008-12-04)
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