Women's Health Weekly
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Drug Resistance
Research from University of Tennessee in the area of drug resistance described
December 4th, 2008
According to recent research published in the journal Drug Metabolism and Disposition, "Increasingly, it is recognized that commensal microflora regulate epithelial cell processes through the dynamic interaction of pathogen-associated molecular patterns and host pattern recognition receptors such as Toll-like receptor 4 (TLR4). We therefore investigated the effects of bacterial lipopolysaccharide (LPS) on intestinal P-glycoprotein (P-gp) expression and function." "Human SW480 (P-gp+/TLR4+) and Caco-2 (P-gp+/TLR4+) cells were treated with medium control or LPS (100 ng/ml) for 24 h prior to study. P-gp function was assessed by measuring the intracellular...
Source: Women's Health Weekly (2008-12-04)
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