New research, 'Overexpression of indoleamine 2,3-dioxygenase in human endometrialcarcinoma cells induces rapid tumor growth in a mouse xenograft model,' is the subject of a report. "Indoleamine 2,3-dioxygenase (IDO) is a tryptophan-catabolizing enzyme that induces immune tolerance in mice. Our prior study showed that high tumoral IDO expression in endometrial cancer tissues correlates with disease progression and impaired patient survival," scientists in Nagoya, Japan report.
"The purpose of the present study was to clarify the functional role of IDO in human endometrial cancer cells and to investigate the therapeutic potential of IDO inhibitors. IDO cDNA was...
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