Women's Health Weekly
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Breast Cancer
Researchers at Pennsylvania State University have published new data on breast cancer
December 11th, 2008
"Metastatic breast cancer cells (BCs) colonize a mineralized three-dimensional (3D) osteoblastic tissue (OT) grown from isolated pre-osteoblasts for up to 5 months in a specialized bioreactor. Sequential stages of BC interaction with OT include BC adhesion, penetration, colony formation, and OT reorganization into ''Indian files'' paralleling BC colonies, heretofore observed only in authentic pathological cancer tissue," researchers in the United States report. "BCs permeabilize OT by degrading the extra-cellular collagenous matrix (ECM) in which the osteoblasts are embedded. OT maturity (characterized by culture age and cell phenotype) profoundly affects the patterns...
Source: Women's Health Weekly (2008-12-11)
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