Women's Health Weekly
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Breast Cancer
Investigators at Chosun University zero in on breast cancer
December 18th, 2008
"MCF-7/ADR cells, a doxorubicin-resistant human breast cancer cell line, have acquired resistance to several anti-cancer chemotherapeutic agents, such as anthracyclines and taxol. Here, we found that MCF-7/ADR cells produced lower levels of vascular endothelial growth factor (VEGF) than control MCF-7 cells," scientists in South Korea report. "Molecular analyses using Western blots and reporter constructs containing either the human VEGF promoter or a minimal promoter for the transcription factor, hypoxia-inducible factor-1 (HIF-1), supported the involvement of HIF-1 alpha in the down-regulation of VEGF transcription in MCF-7/ADR cells. In addition, the basal activities...
Source: Women's Health Weekly (2008-12-18)
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