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Women's Health Weekly

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Breast Cancer



Research from S. Mayer and colleagues provide new insights into breast cancer



December 18th, 2008

" CD44 is a cell surface glycoprotein involved in cell-cell and cell-substrate interactions, which may be shed or released into circulation by proteolytic enzymatic mechanisms. Alternative splicing of CD44 and aberrant levels of soluble CD44 variants in the serum of cancer patients have been correlated to tumor progression and metastasis in different tumors including breast cancer," researchers in Freiburg, Germany report.

"In this study we evaluated the clinical value of CD44 serum levels (sCD44) in patients with primary breast cancer. Concentrations of soluble isoforms sCD44std, sCD44v5 and sCD44v6 were determined with a sensitive ELISA and normalized against the...


Source: Women's Health Weekly (2008-12-18)

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