Women's Health Weekly
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Breast Cancer
Research from University of California has provided new data on breast cancer
December 18th, 2008
"The ErbB2 receptor tyrosine kinase is overexpressed in similar to 25% of breast tumors and contributes to poor patient prognosis and therapeutic resistance. Here, we examine the role of the recently discovered ErbB negative regulator LRIG1 in ErbB2(+) breast cancer," scientists writing in the journal Cancer Research report. "We observe that LRIG1 protein levels are significantly suppressed in ErbB2-induced mammary tumors in transgenic mice as well as in the majority of ErbB2(+) human breast tumors. These observations raise the possibility that LRIG1 loss could contribute to the initiation or growth of ErbB2(+) breast tumors. RNA interference-mediated knockdown...
Source: Women's Health Weekly (2008-12-18)
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