Women's Health Weekly
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Breast Cancer
Research from University of Pittsburgh in breast cancer provides new insights
December 18th, 2008
According to recent research published in the Journal of Cellular Biochemistry, "Her-2/neu (ErbB2) is a transmembrane tyrosine kinase and acts as a co-receptor for the other EGFR family members. It is well known that high expression of Her-2/neu is associated with a poor prognosis in breast cancer." "Quercetin, a flavonoid present in many vegetables and fruits, has been studied extensively as a chemoprevention agent in several cancer models. In this study, we observed that quercetin decreased the level of Her-2/neu protein in time- and dose-dependent manners and also inhibited the downstream survival PI3K-Akt signaling pathway in Her-2/ neu-overexpressing breast...
Source: Women's Health Weekly (2008-12-18)
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