Women's Health Weekly
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Breast Cancer
Research on breast cancer detailed by S.K. Sharma and co-authors
December 18th, 2008
"Synthesis of 4-amino-4,6-androstadiene-3,17-dione 7, an analog of formestane used in breast cancer therapy as an aromatase inhibitor, from 4-acetoxy-4-androstene-3,17-dione 2 is described," scientists writing in the journal Bioorganic & Medicinal Chemistry Letters report. "This is the first report of a 4-amino diene (4,6) system in this series of molecules. The new (7) and reported molecules were screened by the National Cancer Institute (NCI, Bethesda, USA) for in vitro antitumor activity against 60 human cancer cell lines," wrote S.K. Sharma and colleagues. The researchers concluded: "Molecule 7 showed best activity against breast cancer...
Source: Women's Health Weekly (2008-12-18)
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