Women's Health Weekly
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Breast Cancer
Research reports from K.L. Gorringe and co-authors provide new insights into breast cancer
December 18th, 2008
"Chromodomain, helicase, DNA binding 5 (CHD5) is a member of a subclass of the chromatin remodeling Swi/Snf proteins and has recently been proposed as a tumor suppressor in a diverse range of human cancers. We analyzed all 41 coding exons of CHD5 for somatic mutations in 123 primary ovarian cancers as well as 60 primary breast cancers using high-resolution melt analysis," scientists in Melbourne, Australia report. "We also examined methylation of the CHD5 promoter in 48 ovarian cancer samples by methylation-specific single-stranded conformation polymorphism and bisulfite sequencing. In contrast to previous studies, no mutations were identified in the breast cancers, but...
Source: Women's Health Weekly (2008-12-18)
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