Women's Health Weekly
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Breast Cancer
Research results from N.E. Torbett and colleagues update understanding of breast cancer
December 18th, 2008
"The PI3K (phosphoinositide 3-kinase) pathway regulates cell proliferation, Survival and migration and is consequently of great interest for targeted cancer therapy. Using a panel of small-molecule PI3K isoform-selective inhibitors in a diverse set of breast cancer cell lines, we have demonstrated that the biochemical and biological responses were highly variable and dependent on the genetic alterations present. pl 10 alpha inhibitors were generally effective in inhibiting the phosphorylation of PKB (protein kinase B)/Akt and S6, two downstream components of PI3K signalling, in most cell lines examined," scientists writing in the Biochemical Journal report. "In...
Source: Women's Health Weekly (2008-12-18)
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