Women's Health Weekly
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Cancer
Studies from Johns Hopkins University, Medical Department yield new data on cancer
December 18th, 2008
According to recent research from the United States, "The cyclooxygenase (COX) pathway is currently targeted for therapeutic intervention in different cancers. We have previously shown that silencing of COX-2 in the poorly differentiated metastatic breast cell line MDA-MB-231 by RNA interference markedly delayed tumor onset and inhibited metastasis." "To understand the functional effects of COX-2 silencing underlying the inhibition of tumor growth and metastasis previously reported, we investigated changes in these cells for a number of cancer-associated phenotypes. Cyclooxygenase-2-silenced cells were less able to acidify tissue culture medium, a response that could...
Source: Women's Health Weekly (2008-12-18)
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