Women's Health Weekly
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Carcinoma
Findings from M. Arafa and co-researchers advance knowledge in carcinoma
December 18th, 2008
In this recently published study, investigators in Liege, Belgium conducted a study "To identify a DNA methylation signature of endometrioid carcinoma of the endometrium (EEC) in the early stages of endometrial carcinogenesis. Archival biopsy specimens of 39 EECs, 14 cases of atypical hyperplasia (AH), 11 histologically normal endometrial tissues adjacent to EECs and 24 normal control endometrial samples were retrieved." "The cases were tested by quantitative methylation-specific polymerase chain reaction with primers hybridizing in the promoter regions of five genes frequently methylated in human cancer (RASSF1A, RARb2, P16, MGMT and GSTPi). Twenty-nine of 39 (74%)...
Source: Women's Health Weekly (2008-12-18)
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