Women's Health Weekly
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Breast Cancer
Findings from INSERM advance knowledge in breast cancer
December 25th, 2008
According to recent research from Montpellier, France, "We have reported recently that the chemokine interleukin 8 (IL-8)/CXCL8 was overexpressed in invasive estrogen receptor (ER alpha)-negative breast cancer cells compared with ER alpha-positive breast cancer cells. We now demonstrate that histone deacetylases (HDACs) play an essential role in the regulation of IL-8 gene expression in ER alpha-positive MCF-7 breast cancer cells." "Treatment of MCF-7 cells with the HDAC inhibitor trichostatin A (TSA) led to a strong up-regulation of IL-8 protein and RNA levels in MCF-7 cells. The up-regulation of IL-8 in MCF-7 cells was time- and concentration-dependent. Moreover,...
Source: Women's Health Weekly (2008-12-25)
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