Women's Health Weekly
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Carcinoma
Data from C. Costa et al provide new insights into carcinoma
December 25th, 2008
According to recent research published in the journal Virchows Archiv, "ERBB2, a ligand-less membrane receptor, is frequently overexpressed in a number of human tumors, contributing to uncontrolled cell proliferation. In some cases, gene amplification correlates with protein overexpression and predicts response to trastuzumab." "We analyzed the expression of ERBB2 in a group of 40 patients diagnosed with infiltrating squamous cervical carcinomas (ISCC) using a microarray. Immunochemistry was performed using two different antibodies, one against the extramembrane domain and the other one for the intramembrane domain. Ten of the 40 cases included in the study could...
Source: Women's Health Weekly (2008-12-25)
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