Women's Health Weekly
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Chlamydia
Scientists at Pennsylvania State University discuss research in chlamydia
December 25th, 2008
According to a study from the United States, "The class Ic ribonucleotide reductase from Chlamydia trachomatis (Ct) uses a stable Mn(IV)/Fe(III) cofactor to initiate nucleotide reduction by a free-radical mechanism. Extended X-ray absorption fine structure (EXAFS) spectroscopy and density functional theory (DFT) calculations are used to postulate a structure for this cofactor." "Fe and Mn K-edge EXAFS data yield an intermetallic distance of similar to 2.92 angstrom. The Mn data also suggest the presence of a short 1.74 angstrom Mn-O bond. These metrics are compared to the results of DFT calculations on 12 cofactor models derived from the crystal structure of the...
Source: Women's Health Weekly (2008-12-25)
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