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Women's Health Weekly

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Life Sciences



New life sciences study findings have been published by scientists at Fudan University



December 25th, 2008

According to recent research from Shanghai, People's Republic of China, "The human E-cadherin is a single transmembrane domain protein involved in Ca2+-dependent cell-cell adhesion. In a previous study, we demonstrated that all of four potential N-glycosylation sites in E-cadherin are occupied by N-glycans in human breast carcinoma cells in vivo and the elimination of N-glycan at Asn-633 dramatically affected E-cadherin expression and made it degraded."

"In this study we investigated the molecular mechanism of E-cadherin, which lacks N-glycosylation at Asn-633 (M4), degradation and the role of the N-glycan at Asn-633 in E-cadherin folding. We treated cells stably...


Source: Women's Health Weekly (2008-12-25)

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