Breast Cancer Clinical Trial
Research from College of Medicine, Department of Oncology in breast cancer clinical trial provides new insights
Published in Women's Health Weekly, December 25th, 2008
A new study, 'Evaluation of lapatinib and topotecan combination therapy: tissue culture, murine xenograft, and phase I clinical trial data,' is now available. In this recent report, researchers in the United States conducted a study "Topotecan resistance can result from drug efflux by P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP) as well as survival signals initiated by epidermal growth factor receptor family members. The present studies were done to determine the effect of combining topotecan and the dual epidermal growth factor receptor/HER2 inhibitor lapatinib in tissue culture, a murine xenograft model, and a phase I clinical trial."
"The effects...
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