Women's Health Weekly
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Breast Cancer Therapy
Investigators at H. Lee Moffitt Cancer Center zero in on breast cancer therapy
December 25th, 2008
Data detailed in 'MicroRNA-221/222 negatively regulates estrogen receptor alpha and is associated with tamoxifen resistance in breast cancer' have been presented. "A search for regulators of estrogen receptor alpha (ERalpha) expression has yielded a set of microRNAs (miRNAs) for which expression is specifically elevated in ERalpha-negative breast cancer. Here we show distinct expression of a panel of miRNAs between ERalpha-positive and ERalpha-negative breast cancer cell lines and primary tumors," researchers in the United States report. "Of the elevated miRNAs in ERalpha-negative cells, miR-221 and miR-222 directly interact with the 3'-untranslated region of ERalpha....
Source: Women's Health Weekly (2008-12-25)
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