Women's Health Weekly
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Breast Cancer
Research from I. Vanderauwera and co-researchers in the area of breast cancer published
January 1st, 2009
"Aberrant methylation of the adenomatous polyposis coli (APC) gene promoter occurs in about 40% of breast tumours and has been correlated with reduced APC protein levels. To what extent epigenetic alterations of the APC gene may differ according to specific breast cancer phenotypes, remains to be elucidated," researchers in Antwerp, Belgium report. "Our aim was to explore the role of APC methylation in the inflammatory breast cancer (IBC) phenotype. The status of APC gene promoter hypermethylation was investigated in DNA from normal breast tissues, IBC and non-IBC by both conventional and real-time quantitative methylation-specific PCR (MSP). APC methylation levels were...
Source: Women's Health Weekly (2009-01-01)
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