Women's Health Weekly
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Breast Cancer
Research on breast cancer described by L.W.M. Loo and colleagues
January 1st, 2009
According to recent research from the United States, "The two main histological types of infiltrating breast cancer, lobular (ILC) and the more common ductal (IDC) carcinoma are morphologically and clinically distinct. To assess the molecular alterations associated with these breast cancer subtypes, we conducted a whole-genome study of 166 archival estrogen receptor (ER)-positive tumors (89 IDC and 77 ILC) using the Affymetrix GeneChip (R) Mapping I OK Array to identify sites of loss of heterozygosity (LOH) that either distinguished, or were shared by, the two phenotypes." "We found single nucleotide polymorphisms (SNPs) of high-frequency LOH (>50%) common to both...
Source: Women's Health Weekly (2009-01-01)
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