Women's Health Weekly
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Breast Cancer
Studies from University of British Columbia further understanding of breast cancer
January 1st, 2009
According to recent research from Vancouver, Canada, "The Y-box binding protein-1 (YB-1) is a transcription/translation factor that is highly expressed in primary breast tumors where it is consistently associated with poor survival. It induces human epidermal growth factor receptor (her-2) along with its dimerization partner egfr by directly binding to their promoters." "In addition to promoting growth by inducing receptor tyrosine kinases, YB-1 also protects cells against apoptosis through mechanisms that have not been fully revealed. Given this, we addressed whether YB-1 might be an eventual therapeutic target for breast cancer by inhibiting it with small interfering...
Source: Women's Health Weekly (2009-01-01)
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