American Society for Cell Biology
Stopping ovarian cancer by blocking proteins coded by notorious gene
Published in Women's Health Weekly, January 1st, 2009
Ovarian cancer cells are "addicted" to a family of proteins produced by the notorious oncogene, MYC, and blocking these Myc proteins halts cell proliferation in the deadliest cancer of the female reproductive system, according to a presentation by University of California, Berkeley scientists at the American Society for Cell Biology (ASCB) 48th Annual Meeting, Dec. 13-17, 2008 in San Francisco.
In 30-60 percent of human ovarian tumors, MYC is overly active, or amplified, usually as a result of extra chromosomal copies of the cancer-causing gene.
The extra MYC encourages the ovarian cells to manufacture too much c-Myc, a protein that regulates other...
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