Enzyme Research

New enzyme research study findings have been reported by researchers at University of Strasbourg

Published in Women's Health Weekly, January 1st, 2009

According to recent research published in the journal Oncogene, "The substrate of matrix metalloproteinase 11 (MMP11) remains unknown. We have recently shown that MMP11 is a negative regulator of adipogenesis, able to reduce and even to revert mature adipocyte differentiation."

"Here, we have used mouse 3T3L1 cells and human U87MG and SaOS cells to show that MMP11 cleaves the native alpha 3 chain of collagen VI, which is an adipocyte-related extracellular matrix component. It is known that extracellular proteolytic processing of this chain is required for correct collagen VI folding. Interestingly, MMP11-deficient fat tissue is less cohesive and exhibits collagen...

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Source: Women's Health Weekly (2009-01-01)

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