Women's Health Weekly
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Breast Cancer
Study findings from Genentech, Inc. provide new insights into breast cancer
January 15th, 2009
According to recent research published in the journal Cancer Research, "HER2 is a validated target in breast cancer therapy. Two drugs are currently approved for HER2-positive breast cancer: trastuzumab (Herceptin), introduced in 1998, and lapatinib (Tykerb), in 2007." "Despite these advances, some patients progress through therapy and succumb to their disease. A variation on antibody-targeted therapy is utilization of antibodies to deliver cytotoxic agents specifically to antigen-expressing tumors. We determined in vitro and in vivo efficacy, pharmacokinetics, and toxicity of trastuzumab-maytansinoid (microtubule-depolymerizing agents) conjugates using disulfide...
Source: Women's Health Weekly (2009-01-15)
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