Women's Health Weekly
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Breast Cancer
Study results from Y. Nikolsky et al provide new insights into breast cancer
January 15th, 2009
According to recent research from the United States, "A single cancer cell contains large numbers of genetic alterations that in combination create the malignant phenotype. However, whether amplified and mutated genes form functional and physical interaction networks that could explain the selection for cells with combined alterations is unknown." "To investigate this issue, we characterized copy number alterations in 191 breast tumors using dense single nucleotide polymorphism arrays and identified 1,747 genes with copy number gain organized into 30 amplicons. Amplicons were distributed unequally throughout the genome. Each amplicon had distinct enrichment pattern in...
Source: Women's Health Weekly (2009-01-15)
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