Women's Health Weekly
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Cancer
Studies in the area of cancer reported from P.J.A. Eichhorn and co-researchers
January 15th, 2009
According to recent research published in the journal Cancer Research, "Small molecule inhibitors of HER2 are clinically active in women with advanced HER2-positive breast cancer who have progressed on trastuzumab treatment. However, the effectiveness of this class of agents is limited by either primary resistance or acquired resistance." "Using an unbiased genetic approach, we performed a genome wide loss-of-function short hairpin RNA screen to identify novel modulators of resistance to lapatinib, a recently approved anti-HER2 tyrosine kinase inhibitor. Here, we have identified the tumor suppressor PTEN as a modulator of lapatinib sensitivity in vitro and in...
Source: Women's Health Weekly (2009-01-15)
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